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Wednesday, July 26, 2006
By Dr. John Ray

Fabulous news if it works: “In a world first, Melbourne scientists have developed a once-a-day pill that they claim may cure Alzheimer’s disease. Human trials of the drug start next month. The drug – called PBT2 – was developed by a team from the Mental Health Research Institute of Victoria in collaboration with Melbourne-based Prana Biotechnology. “It is a major breakthrough and very much a Melbourne discovery,” said Prof George Fink, the director of the Mental Health Research Institute. “Though much depends on the next phase of human clinical trials . . . early results indicate this drug offers hope to people with Alzheimer’s disease,” he said. The revolutionary drug stops the buildup of a protein called amyloid. Many scientists accept amyloid is a major cause of Alzheimer’s as the protein is thought to cause the brain to “rust”. Prof Fink said the drug could significantly prevent Alzheimer’s developing or delay the on-set of the brain disease for many years. Early clinical testing has confirmed the drug is fast-acting. Levels of amyloid dropped by 60 per cent within 24 hours of a single dose. It found also that PBT2 suppresses the impairment of memory function. More human studies begin in Sweden next month and Australians will join a major international trial of the drug next year.”

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